36th ECNP Congress Barcelona (Spain) – 7-10th of October, 2023
Del 7 al 10 d’octubre de 2023, Barcelona (Espanya) va acollir el 36è Congrés de l’European College of Neuropsychopharmacology (ECNP), un dels esdeveniments més importants en neurociència, psiquiatria i neuropsicofarmacologia a nivell europeu i internacional.
La Dra. Margarita Torrente, Coordinadora de l’Àrea de Neuropsicologia i Recerca de l’Institut Lerín Neurocognitive i investigadora principal del projecte DEM-BIOTA, ha supervisat l’elaboració dels dos pòsters científics presentats en el congrés. El neuropsicòleg Cristian Cabrera, també de l’Institut, ha aportat la seva experiència en el marc científic. La Sra. Nerea Carrión i el Sr. David Mateo han estat els responsables de la producció i la presentació final dels pòsters durant l’esdeveniment.
Investigacions com DEM-BIOTA subratllen la importància de mantenir un estil de vida saludable i una dieta equilibrada per a prevenir el desenvolupament de demències. Dietes específiques, com la dieta Mediterrània, així com aliments i suplements com els prebiòtics i probiòtics, podrien contribuir a frenar el deteriorament cognitiu a causa de la seva capacitat modulatòria de la microbiota intestinal.
Exploring the influence of gut microbiota on cognitive decline in Alzheimer’s disease
Mateo D, Cabrera C, Carrión N, Marquès M, Forcadell E, Zaragoza J, González JM, Cavallé Ll, Moral A, Pino M, Yerga B, Domingo JL, Torrente M
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and is the most common form of dementia worldwide. While the exact cause of AD is still unknown, there are several proteins associated with the development of cognitive impairment. Interestingly, many of these proteins are produced by the gut microbiota (GMB). Recent studies suggest that the GMB may play a role in the pathogenesis of dementia by influencing brain function through the gut-brain axis. Imbalances in the GMB, a condition referred to as dysbiosis, can potentially disrupt the integrity of the gut and blood-brain barriers. This disruption may activate immune responses and increase oxidative stress levels. Consequently, these processes can contribute to the aggregation of amyloid-beta (Aβ) plaques, which are a hallmark of AD. Additionally, dysbiosis-induced oxidative stress and neuroinflammation can further exacerbate the progression of the disease. (Resum de la participació al congrés en mateix format)
REFERÈNCIA: García, D. M., Cabrera, C., Carrión, N., Marquès, M., Forcadell, E., Zaragozà, J., … & Torrente, M. (2023). Exploring the influence of gut microbiota on cognitive decline in Alzheimer’s disease. Neuroscience Applied, 2, 103537.
Preliminary study of the modifiable risk factors and protective factors in an Alzheimer Disease sample
Carrión N, Mateo D, Cabrera C, Marquès M, Vicens P, Heredia L, Forcadell E, Zaragoza J, Torrente M.
Abstract: The increasing life expectancy has led to an increase in pathologies associated with age, such as dementias, being Alzheimer’s disease (AD) the most prevalent. AD is a neurodegenerative illness that entails a long-term decline in cognitive and functional skills, and behavioral alterations, affecting their activities of daily living. The lack of effective treatments has led to an increased interest in prevention and risk factors studies for this disease. Protective factors are associated with a lower risk of dementia incidence, such as cognitive reserve, social engagement, physical activity and healthy diet. Risk factors as cardiovascular diseases, hypertension, diabetes mellitus or obesity, can increase the incidence of AD. The aim of this study is to investigate the relationship between protective factors, risk factors and cognitive variables in a sample of healthy elderly and AD patients. (Resum de la participació al congrés en mateix format)
REFERÈNCIA: Fernández, N. C., Mateo, D., Cabrera, C., Marquès, M., Vicens, P., Heredia, L., … & Torrente, M. (2023). Preliminary study of the modifiable risk factors and protective factors in an Alzheimer’s disease sample. Neuroscience Applied, 2, 103538.